Endocrine Abstracts

Objective: Recently rare heterozogous AMH genetic variants have been identified in women with polycystic ovary syndrome (PCOS) that result in reduced AMH signaling. However, the exact functional mechanism remains unknown. Therefore, we have performed functional analyses to analyze the processing, secretion and signaling of these PCOS-specific AMH rare variants.Methods: Six PCOS-specific AMH variants containing mutations (V12G, P151S, P270S, P352S, P362S,...

Binge-eating disorder is the most prevalent eating disorder diagnosed, affecting three times more women than men. It is characterised by binge-eating episodes: the rapid consumption of a large amount of food, without needing the calories. The gut hormone ghrelin stimulates appetite and reward signalling, and loss of its receptor reduces binge-eating behaviour in male mice. We aimed to examine the influence of ghrelin itself on binge-eating behaviour in mice of both sexes. 5-we...

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women in their reproductive years, is defined by two out of the following three criteria: hyperandrogenism, oligo/anovulation, and polycystic ovaries. Affected women are often obese and insulin-resistant. Recently, we developed a mouse PCOS-model through chronic exposure to dihydrotestosterone (DHT). Here, we studied whether the PCOS-phenotype remains after withdrawal of DHT treatment, which would more clo...

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women in their reproductive age. Based on the Rotterdam criteria PCOS is defined by two out of the following three criteria: hyperandrogenism, oligo/anovulation, and polycystic ovaries. In addition, PCOS patients are often abdominal obese, which can lead to insulin resistance. The subsequent increased insulin levels stimulate the ovary to further increased androgen production. Thus, the elevated androgen...

Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders of premenopausal women. It is also the most frequent cause of female infertility and affects 6.5–8% of women in their reproductive age. Two out of three criteria diagnoses PCOS: oligo- or anovulation, clinical or biochemical signs of hyperandrogenism and polycystic ovaries at ultrasound. In addition, PCOS women frequently display features of the metabolic syndrome, such as abdomin...

Polycystic ovary syndrome (PCOS) is a disorder associated with infertility and metabolic disturbances. Ovaries of PCOS women contain an increased number of growing follicles. Such an ovarian phenotype is also observed in mice lacking the ovary-specific growth factor anti-Müllerian hormone (AMH). To determine the interaction between ovarian and metabolic function, we studied the metabolic phenotype of mice lacking AMH signaling as a model for an altered profile in ovarian ...